Restless legs syndrome outside the blood-brain barrier--exacerbation by domperidone in Parkinson's disease.
Identifieur interne : 000C82 ( Main/Exploration ); précédent : 000C81; suivant : 000C83Restless legs syndrome outside the blood-brain barrier--exacerbation by domperidone in Parkinson's disease.
Auteurs : S. Rios Romenets [Canada] ; Y. Dauvilliers ; V. Cochen De Cock ; B. Carlander ; S. Bayard ; C. Galatas ; C. Wolfson ; R B PostumaSource :
- Parkinsonism & related disorders [ 1873-5126 ] ; 2013.
English descriptors
- KwdEn :
- Aged, Blood-Brain Barrier (physiopathology), Domperidone (adverse effects), Domperidone (therapeutic use), Dopamine Antagonists (adverse effects), Dopamine Antagonists (therapeutic use), Female, Humans, Male, Middle Aged, Parkinson Disease (complications), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Prevalence, Restless Legs Syndrome (complications), Restless Legs Syndrome (drug therapy), Restless Legs Syndrome (physiopathology), Treatment Outcome.
- MESH :
- chemical , adverse effects : Domperidone, Dopamine Antagonists.
- complications : Parkinson Disease, Restless Legs Syndrome.
- drug therapy : Parkinson Disease, Restless Legs Syndrome.
- physiopathology : Blood-Brain Barrier, Parkinson Disease, Restless Legs Syndrome.
- chemical , therapeutic use : Domperidone, Dopamine Antagonists.
- Aged, Female, Humans, Male, Middle Aged, Prevalence, Treatment Outcome.
Abstract
Models of dopaminergic function in restless legs focus on central dopaminergic neurons. Domperidone, a peripheral dopamine blocker that cannot cross the blood-brain barrier, is commonly used in Parkinson's disease. After encountering a case of restless legs syndrome that dramatically worsened with domperidone, we assessed whether Parkinson's patients may have exacerbation of restless legs with domperidone.
DOI: 10.1016/j.parkreldis.2012.07.019
PubMed: 22922159
Affiliations:
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Le document en format XML
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Rios Romenets</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, McGill University, Montreal General Hospital, 1650 Cedar Ave., Montreal L 7-312, Quebec H3G1A4, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Neurology, McGill University, Montreal General Hospital, 1650 Cedar Ave., Montreal L 7-312, Quebec H3G1A4</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Dauvilliers, Y" sort="Dauvilliers, Y" uniqKey="Dauvilliers Y" first="Y" last="Dauvilliers">Y. Dauvilliers</name></author><author><name sortKey="Cochen De Cock, V" sort="Cochen De Cock, V" uniqKey="Cochen De Cock V" first="V" last="Cochen De Cock">V. Cochen De Cock</name></author><author><name sortKey="Carlander, B" sort="Carlander, B" uniqKey="Carlander B" first="B" last="Carlander">B. Carlander</name></author><author><name sortKey="Bayard, S" sort="Bayard, S" uniqKey="Bayard S" first="S" last="Bayard">S. Bayard</name></author><author><name sortKey="Galatas, C" sort="Galatas, C" uniqKey="Galatas C" first="C" last="Galatas">C. Galatas</name></author><author><name sortKey="Wolfson, C" sort="Wolfson, C" uniqKey="Wolfson C" first="C" last="Wolfson">C. Wolfson</name></author><author><name sortKey="Postuma, R B" sort="Postuma, R B" uniqKey="Postuma R" first="R B" last="Postuma">R B Postuma</name></author></analytic><series><title level="j">Parkinsonism & related disorders</title><idno type="eISSN">1873-5126</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Blood-Brain Barrier (physiopathology)</term><term>Domperidone (adverse effects)</term><term>Domperidone (therapeutic use)</term><term>Dopamine Antagonists (adverse effects)</term><term>Dopamine Antagonists (therapeutic use)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (physiopathology)</term><term>Prevalence</term><term>Restless Legs Syndrome (complications)</term><term>Restless Legs Syndrome (drug therapy)</term><term>Restless Legs Syndrome (physiopathology)</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Domperidone</term><term>Dopamine Antagonists</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Blood-Brain Barrier</term><term>Parkinson Disease</term><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Domperidone</term><term>Dopamine Antagonists</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prevalence</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Models of dopaminergic function in restless legs focus on central dopaminergic neurons. Domperidone, a peripheral dopamine blocker that cannot cross the blood-brain barrier, is commonly used in Parkinson's disease. After encountering a case of restless legs syndrome that dramatically worsened with domperidone, we assessed whether Parkinson's patients may have exacerbation of restless legs with domperidone.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Québec</li></region><settlement><li>Montréal</li></settlement><orgName><li>Université McGill</li></orgName></list><tree><noCountry><name sortKey="Bayard, S" sort="Bayard, S" uniqKey="Bayard S" first="S" last="Bayard">S. Bayard</name><name sortKey="Carlander, B" sort="Carlander, B" uniqKey="Carlander B" first="B" last="Carlander">B. Carlander</name><name sortKey="Cochen De Cock, V" sort="Cochen De Cock, V" uniqKey="Cochen De Cock V" first="V" last="Cochen De Cock">V. Cochen De Cock</name><name sortKey="Dauvilliers, Y" sort="Dauvilliers, Y" uniqKey="Dauvilliers Y" first="Y" last="Dauvilliers">Y. Dauvilliers</name><name sortKey="Galatas, C" sort="Galatas, C" uniqKey="Galatas C" first="C" last="Galatas">C. Galatas</name><name sortKey="Postuma, R B" sort="Postuma, R B" uniqKey="Postuma R" first="R B" last="Postuma">R B Postuma</name><name sortKey="Wolfson, C" sort="Wolfson, C" uniqKey="Wolfson C" first="C" last="Wolfson">C. Wolfson</name></noCountry><country name="Canada"><region name="Québec"><name sortKey="Rios Romenets, S" sort="Rios Romenets, S" uniqKey="Rios Romenets S" first="S" last="Rios Romenets">S. Rios Romenets</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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